Study 01
Creatine Monohydrate
A 2024 systematic review and meta-analysis of 16 randomized controlled trials confirmed that creatine monohydrate supplementation produces measurable benefits for memory, attention, and information processing speed — adding to decades of evidence for muscle and strength gains. The most-studied supplement on the shelf, with good reason.
Source: Frontiers in Nutrition, 2024 — systematic review & meta-analysis (Xu et al.).
Found in: The House Power
Study 02
KSM-66® Ashwagandha
A 2025 systematic review and meta-analysis of 15 randomized controlled trials covering 873 patients found ashwagandha supplementation produces significant reductions in cortisol, stress, and anxiety versus placebo. KSM-66® is the most-studied standardized extract.
Source: BJPsych Open, 2025 — systematic review & meta-analysis (Bachour et al.).
Found in: The House Tranquil · The House Greens
Study 03
Magnesium Glycinate
Magnesium glycinate is the chelated form clinically associated with improved sleep quality, reduced stress markers, and better absorption than oxide or citrate. Around half of US adults fall short of the recommended daily intake — supplementation closes a real gap.
Source: Reviewed in Nutrients (multiple), and the NIH Office of Dietary Supplements.
Found in: The House Calm
Study 04
Vitamin D3 (Cholecalciferol)
Vitamin D3 supplementation has decades of clinical evidence supporting bone density, immune balance, and mood regulation. An estimated 35% of US adults are deficient — a gap that supplementation reliably closes when taken consistently with a fat source for absorption.
Source: Reviewed in JAMA, The Lancet, and the NIH Office of Dietary Supplements.
Found in: The House Sunshine · The House Multi · The House Radiance
Study 05
Omega-3 EPA + DHA
Long-chain marine omega-3s (EPA and DHA) are among the most-studied supplements in nutrition science. Clinical trials consistently associate adequate intake with cardiovascular benefits, reduced inflammatory markers, and cognitive support — particularly when paired with a low-omega-6 diet.
Source: Reviewed in Circulation, JAMA, and meta-analyses across 100,000+ participants.
Found in: The House Flow
Study 06
NAD+ Precursors
NAD+ levels decline with age, and emerging clinical research suggests precursor supplementation can increase cellular NAD+ levels and support energy metabolism. Combined with antioxidants like resveratrol and quercetin, the stack targets cellular health at its most fundamental level.
Source: Reviewed in Cell Metabolism (Imai & Guarente) and ongoing trials at Harvard, Washington University.
Found in: The House NAD+
Research summarized above examines individual supplement ingredients and active compounds in published clinical studies. Daniel's House products contain these actives at supplemental doses and are not intended to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Individual results vary. Consult a healthcare professional before starting any new supplement, especially if pregnant, nursing, taking medication, or under 18.